Human Development
Lab Lecture
I). Gametes
A). Structure of sperm
1). Head
acromere.
2). Midpiece
3). Tail
B). Oocyte
1). Primary oocyte:
2). Secondary oocyte:
offspring inherit mitochondrial DNA from their mothers.
II). How does the sperm penetrate the secondary oocyte?
1. Oocyte encapsulated
2. The sperm becomes capacitated (readied)corna radiata
zona pellucida
After ejaculation the sperm membranes become fragile
3. It takes more than one acromere to break through the capsule
4. Connect to the sperm receptors
5. membranes merge
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III). Immediately after fertilization occurs
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Fertilization occurs
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sperm loses tail
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secondary oocyte undergoes meiosis II
(
meiosis I occurred during the female’s fetal development)eject polar body
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female pronuclei
male pronuclei
form a mitotic spindle
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produce a diploid zygote.
undergoes cleavage
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IV). Development
Zygote:
Embryo:
Fetus:
V). Zygote Development
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Zygote formation
cleavage
4 cells
Morula
Blastocyst
differentiating into:
Inner cell mass:
Trophoblast cells:
VI). Embryonic Membranes
develop during gastrula
1). Embryonic (Disc) Germ Layers
Ectoderm
Mesoderm
Endoderm
2). Amnion:
3). Yolk Sac:
- part of the gut
- early blood cells
- forms gonads
4). Allantios:
5). Chorion:
VII). Placenta
A). What prevents the normal sloughing off of the uterine wall?
The embryo must maintain the corpus luteum until the placenta can take over its endocrine functions.
human chorionic gonadotropin (hCG)
acts like luteinizing hormone.
B). Formation
Trophoblast
Chorion & chronic villi form:
(Amnion forms around the embryo)
new vessels form, which extend to the embryo
The endometrium the villi forms the placenta.
Fetal side is flat and smooth and slick
Maternal side is bumpy
VII). Fetal Circulation
Blood cells arise in the yolk sac
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spaces appear in mesoderm
(middle germ layer)
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become network
heart, blood vessels, etc.
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by 3.5 weeks heart is formed and beating
VII). Fetal Circulation
Umbilical Vein transport oxygen rich blood
blood enters the liver and the ductus venous
It is than shunted from the right atrium to the left atrium through the foramen ovale
Blood in the descending aorta branches off into the umbilical artery to the placenta
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